If I made the plunge I would get an RME USB audio interface and use Reaper, maybe play around with Bitwig which is also native on Linux. I don't think I would mess with WINE, regardless of other's success stories with it.
I'm glad to see where things have gone in recent years though
[0] https://en.wikipedia.org/wiki/CLever_Audio_Plug-in [1] https://u-he.com/products/diva/
https://www.toneboosters.com/tb_equalizer_pro.html https://tal-software.com/products/tal-eq https://zl-audio.github.io/plugins/zlequalizer2/manual/
(Pitch shifting is easy and widely available, but also trivial to reverse, so it's not good enough.)
I'm mainly interested for anonymity in online gaming, but I could see it also being a helpful privacy measure in other situations.
How do I know which are good / worth trying?
Where do I start?!